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Literature summary extracted from

  • Eggertsen, G.; Olin, M.; Andersson, U.; Ishida, H.; Kubota, S.; Hellman, U.; Okuda, K.I.; Bjorkhem, I.
    Molecular cloning and expression of rabbit sterol 12alpha-hydroxylase (1996), J. Biol. Chem., 271, 32269-32275.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.139 transfection of COS-M6 cells with the coding part of the cDNA Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.139 Mus musculus
-
-
-
1.14.14.139 Oryctolagus cuniculus
-
-
-
1.14.14.139 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.139 liver exclusively expressed in Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.139 7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2
-
 Mus musculus 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
-
 ?
1.14.14.139 7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2
-
 Rattus norvegicus 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
-
 ?
1.14.14.139 7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2
-
 Oryctolagus cuniculus 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.139 7alpha-hydroxy-4-cholest-3-on3 12alpha-monooxygenase
-
 Oryctolagus cuniculus
1.14.14.139 CYP12
-
 Oryctolagus cuniculus
1.14.14.139 HCO 12alpha-hydroxylase
-
 Oryctolagus cuniculus
1.14.14.139 sterol 12alpha-hydroxylase
-
 Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.139 cytochrome P-450
-
 Oryctolagus cuniculus
1.14.14.139 NADPH
-
 Mus musculus
1.14.14.139 NADPH
-
 Oryctolagus cuniculus